The determination of 3-methoxy 4-hydroxy mandelic acid in urine
نویسندگان
چکیده
منابع مشابه
The determination of 3-methoxy 4-hydroxy mandelic acid in urine.
A simple and accurate method for determining 3-methoxy 4-hydroxy mandelic acid in urine is described. The amounts excreted in urine in 24 hours by nine normal subjects and three patients with phaeochromocytoma have been determined.
متن کاملThe Excretion of 4-hydroxy-3-methoxy-mandelic Acid by Children.
Much interest has been shown recently in the urinary excretion of 4-hydroxy-3-methoxy-mandelic acid (HMMA, but also known as VMA). It is accepted that its estimation may assist in the diagnosis of neuroblastoma and phaeochromocytoma, the high excretion usually found with these tumours being well above that possibly due to dietary constitutents, the stress of hospital admission, or recent operat...
متن کاملDetermination of 3-methoxy-4-hydroxymandelic acid in urine.
Five different methods for the determination of 3-methoxy-4-hydroxymandelic acid (vanilmandelic acid, VMA) in urine were compared: a GLC-FID catecholamine metabolite profiling method, an HPLC method with electrochemical detection, the method of Pisano et al. [1962) Clin. Chim. Acta 7, 285-291), a one dimensional paper chromatographic method with diazotized p-nitroaniline staining and the commer...
متن کاملA comparison of methods for determining catechol amines and 3-methoxy-4-hydroxy-mandelic acid in urine.
The chemical laboratory measures used in the diagnosis of pheochromocytoma have been evaluated. Bio-assay, fluorometric, and spectrophotometric methods were used. Urinary VMA and catechol amine values found for normal and hypertensive groups compared well with those reported by other investigators. The quantitative measurement of urinary VMA by means of a proposed ethyl acetate extraction prove...
متن کاملDEVELOPMENT OF A METHOD FOR THE DETERMINATION OF 4-HYDROXY-3-METHOXYMANDELIC ACID (VANILLYLMANDELIC ACID) IN URINE BY PAPER CHROMATOGRAPHY
We have developed a simple and precise paper chromatographic method for the determination of 4-hydroxy-3-methoxymandelic acid (VMA) in urine. Concentrations of VMA in patients with neuroblastoma were increased in comparison to controls. The linearity was excellent in the concentration range tested. The within-assay coefficient of variation for control and patient urine was less than 2.2%. ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1961
ISSN: 0021-9746
DOI: 10.1136/jcp.14.5.502